Anti-Tumor Drugs China Factory Supply High Purity Vorinostat CAS 149647-78-9/51-21-8 Double Clearance with Best Price/Safety Delivery EU/Nz/UK/USA

Basic Info

Model NO.	149647-78-9
MW	272.77
Keyword1	288573-56-8
Keyword2	28578-16-7
Keyword3	236117-38-7
Keyword4	20320-59-6
Xingjiu	100%Delivery
Big Sale	Singapore/Spain/Poland/Finland/Singapore
Hot Sale	UK/EU/USA/UK/Nz
Transport Package	1g
Specification	99%
Trademark	xingjiu
Origin	China
HS Code	29224995

Product Description

100% customs clearance Door -to -door Safety delivery

Product Name	Wholesale Pharmaceutical Intermediate Vorinostat Powder CAS 149647-78-9 Vorinostat Used for Antineoplastic
Appearance	White Powder
Assay	99%min, 98.0% --101.0%
CAS	149647-78-9
MF	C14H20N2O3
Storage Temperature	Cool Dry Place

Product Description

What is Vorinostat ?
Vorinoat is a novel molecularly targeted antitumor drug that induces cell cycle arrest and/or apoptosis through inhibition ofhistonedeacetylase (HDAC). It is the first FDA-approved HDAC inhibitor for the treatment of advanced, resistant, or relapsedcutaneous T-cell lymphoma (CTCL) with significant skin invasion after two systemic regimens.

Description
Vorinostat is the first drug in a new class of anti-cancer agents that inhibit histone deacetylases (HDAC). It was launched as an oral treatment for cutaneous manifestations in patients with cutaneous T-cell lymphoma (CTCL) who have progressive, persistent, or recurrent disease on or following two systemic therapies. HDACs are enzymes that catalyze the removal of the acetyl modification on lysine residues of proteins, including the core nucleosomal histones. Together with their counterpart histone acetyltransferases (HATs), HDACs regulate the acetylation level of the histones, which plays an important role in the regulation of chromatin plasticity and gene transcription. Hypoacetylation of histones is associated with a condensed chromatin structure resulting in the repression of gene transcription, whereas acetylated histones are associated with a more open chromatin structure and activation of transcription. In some cancer cells, there is an overexpression of HDACs, resulting in hypoacetylation of histones. Inhibitors of HDAC are thought to transcriptionally reactivate dormant tumor-suppressor genes by allowing for the accumulation of acetyl groups on histones and an open chromatin structure. Vorinostat inhibits the enzymatic activity of HDAC1, HDAC2, HDAC3, and HDAC6 at nanomolar concentrations (IC50 <86 nM). In vitro, it induces growth arrest, differentiation or apoptosis in a variety of tumor cells. In addition, vorinostat inhibits tumor growth in animal models bearing solid tumors, including breast, prostate, lung and gastric cancers, as well as hematologic malignancies such as multiple myeloma and leukemias.

Company Profile

I 'm Nicole

 

We use door to door transportation.So the transport is very fast ad safe.And we adopt double clear customs.So we can guarantee the safety of goods.Our after-sales service is very advantageous. If there is any problem in the process of transportation, we will bear all the responsibility and all the losses.1)Please do not worry about the quality of our products, we can make sure that this product is safe for everyone.2) Our service is considerate and you can contact us at anytime via whatsapp,telegram and e-mail. we will reply you in time.3) The goods will be delivered and sent to you in accordance with the designated date and our express service is convenient and quick.We guarantee 100% of your packages pass through customs. We have full experience of worldwide shipping especially to North America, Australia and EU.

Parcels will be no encounter customs issues such as Mexico ,Spain, UK, Netherlands, USA, Ireland, France, Germany, Brazil, Italy, and many European countriesWE HAVE SPECIAL SHIPPING WAY delivery to your door ,safe and fast No free samples will be provided

Our Service

1. Competitive price

2. Best quality

3. We are online all the time, if you have any problems, you can contact us at any time, then, we will reply you asp

4. We have our own laboratory and factory, can customize product according to your request

5. We have all kinds of transport mode, can according to your requirements, timely, rapid transportation arrangements

FAQ

• Q1: Can I get some samples?
A: Yes, we can supply the free sample, you need bear the freight charge only.

• Q2: How to pay?
A: PI will be sent first after confirmation of order,enclosed our bank information.Payment by Paypal , T/T, Western Union LC,Alibaba trade assurance

• Q3: What's your MOQ?
A: Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

• Q4: How about delivery leadtime?
A: Delivery lead time: About 5 days after payment confirmed.

• Q5: Is there a discount?
A: Discount according to the quantity and product!

• Q6: How to confirm the Product Quality before placing orders?
A: You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.